MicroRNA Dysregulation Associated with Red Blood Cell Storage
نویسندگان
چکیده
منابع مشابه
Red blood cell storage lesion.
The past two decades have witnessed increased scrutiny regarding efficacy and risk of the once unquestioned therapy of red blood cell (RBC) transfusion. Simultaneously, a variety of changes have been identified within the RBC and storage media during RBC preservation that are correlated with reduced tissue oxygenation and transfusion-associated adverse effects. These alterations are collectivel...
متن کاملEvaluation of Blood Storage Lesions in Leuko-depleted Red Blood Cell Units
Background: Red blood cells (RBCs) undergo biochemical and morphologic alterations during storage that are known as the storage lesions causing decreased RBC quality and are correlated with transfusion reactions in certain groups especially in infants and critically ill patients. Microvesicles (MVs) as one of storage lesions may be derived from various cell types and have key roles in several...
متن کاملClinical effects of red blood cell storage.
BACKGROUND Well-characterized biochemical, structural, and physiological changes occur when red blood cells (RBCs) are stored for a period of time and are collectively called the storage lesion. METHODS Key study results are summarized and contrasted and new data from recently completed randomized controlled trials will be discussed. RESULTS It is unclear whether in vitro changes to RBCs th...
متن کاملAttenuation of Red Blood Cell Storage Lesions with Vitamin C
Stored red blood cells (RBCs) undergo oxidative stress that induces deleterious metabolic, structural, biochemical, and molecular changes collectively referred to as "storage lesions". We hypothesized that vitamin C (VitC, reduced or oxidized) would reduce red cell storage lesions, thus prolonging their storage duration. Whole-blood-derived, leuko-reduced, SAGM (saline-adenine-glucose-mannitol)...
متن کاملRed blood cell storage duration is associated with various clinical outcomes in pediatric cardiac surgery.
BACKGROUND Recommendations on the use of fresh red blood cells (RBCs) in pediatric patients undergoing cardiac surgery are based on limited information. Furthermore, the RBC storage time cut-off of fresh units remains unknown. METHODS Data from 139 pediatric patients who underwent cardiac surgery and received RBCs from a single unit within 14 days of storage were analyzed. To identify the opt...
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ژورنال
عنوان ژورنال: Transfusion Medicine and Hemotherapy
سال: 2018
ISSN: 1660-3796,1660-3818
DOI: 10.1159/000489321